Introduction: Regenerative Medicine for Cardiovascular Disease-A Good Start PART I: STEM CELLS: Chapter 1: Introduction and Overview of Stem Cells Chapter 2: Mechanistic Insights from Pathologic Perspective Chapter 3: Large Animal Models to Study Stem Cell Therapy Section I. Body's Native Repair Mechanisms Chapter 4. Evolution of understanding of the mechanisms of repair Chapter 5: Impact of Age on Stem Cell Function Section II: Autologous Bone Marrow Chapter 6: Bone Marrow Mononuclear Cells Chapter 7: Chronic Limb Ischemia Chapter 8: Chronic/Refractory Angina Chapter 9: Acute Myocardial Infarction A. European Experience: Andreas Zeiher B. US Experience: Jay Traverse Chapter 10: Chronic Ischemic Heart Failure Section III: Autologous Adipose Derived Regenerative Cells Chapter 11: Adipose Tissue Section IV: Allogeneic Alternatives to Autologous Bone Marrow Chapter 12: Overview of MSCs Chapter 13: Allogeneic vs Autologous Source: Comparative Effects Chapter 14: Use of MSCs for AMI Chapter 15: Combined Cell Strategies Chapter 16: Heart Failure Section V: Cardiac Progenitor Cells Chapter 17: C-Kit+ cells Chapter 18: Cardiospheres Section VI: Other Allogeneic Sources of Stem Cells Chapter 19: Umbilical Cord, Placenta, Endometrium Section VII. Genetic Engineering/Cell Transformation Chapter 20: Genetic Engineering of Fibroblasts to Cardiomyocytes Chapter 21: Transformation to inducible Pleuripotent Stem Cells Chapter 22: Transformation to MAPC's Section VIII: METHODS OF DELIVERY: Chapter 23. Transcoronary and Endocardial Chapter 24. Retrograde and Epicardial Part II. TISSUE ENGINEERING: Chapter 25. Epicardial Patch Chapter 26. Matrix Scaffolds Chapter 27. Matrix plus cells Chapter 28. Biomaterial Chapter 29: Organogenesis Part III. GENE THERAPY: Chapter 30: Pre-clinical Identification of target genes Chapter 31: SERCA-2a gene for recovery of inotropic function Chapter 32: SDF-1 Gene for Heart Failure Non-Inotropic Mechanisms Chapter 33: Gene Therapy for Angiogenesis: Chronic Limb Ischemia Chapter 34: Stem Cells Target Gene Transfected Stem Cells Part IV: FUTURE DIRECTIONS: Chapter 35: CCTRN: Past, Present, and Vision for the Future Chapter 36: Signature of Responders-lessons from Bio-Repository Chapter 37: Adjunctive therapy with LVADs for Recovery Chapter 38: Trials in Non-Ischemic Heart Failure Chapter 39: Enhancing Stem Cell Homing for Tissue Repair Chapter 40: Stroke: Pre-Clinical and Clinical Trial Data SUMMARY Skryť popis