Molecular and functional evolution of the adrenomedullin family in vertebrates: what do fish studies tell us? Ligand binding and activation of the CGRP receptor Understanding amylin receptors The CGRP-receptor component protein (RCP): a regulator for CLR signaling The calcitonin peptide family: what can we learn from receptor knockout and transgenic mice Gene targeted mouse models of adrenomedullin signalling Genetic regulation of CGRP and its actions Vascular actions of CGRP and adrenomedullin: mechanisms and potential contribution to inflammation in the cutaneous microvasculature Insights into the function of intermedin/adrenomedullin 2 CGRP and adrenomedullin as pain-related peptides Amylinergic control of ingestive behaviour CGRP receptor antagonists for migraine: challenges and promises Calcitonin receptor (CTR) expression in embryonic, foetal and adult tissues: developmental and pathophysiological implications Future perspectives