PART I. INTRODUCTION Polypharmacology in Drug Discovery PART II. SELECTIVITY OF MARKTETED DRUGS Kinase Inhibitors New Indications for Marketed Drugs Discovery Technologies of New Indications PART III. FIXED-DOSE COMBINATIONS The Growing Market of Fixed-Dose Combinations PART IV. UNSELECTIVE DRUGS IN DRUG DISCOVERY The Growing Importance of Individualising Drugs Drug Discovery Strategies for the Generation of Multi-Target Ligands against Neglected Tropical Diseases Designing-In Approach The Linker Approach (Drug-Conjugates) Merged Multiple Ligands Pharmacophore Generation of Multiple Ligands Cellular Assays PART V. THERAPEUTIC AREAS FOR DESIGNED MULTIPLE LIGANDS 5HT Transporter-Based Multiple Ligands for Depression Multiple Ligands Targeting the Angiotensin System for Hypertension PPAR-Based Multiple Ligands for Metabolic Disease Antibiotics Multiple Ligands in Cancer Therapy Multiple Ligands in Neurodegenerative Diseases Skryť popis