1 BASICS 1.1 Preparation of metalloenzymes (repurposing natural metalloenzymes, direct salt complexation, covalent and non-covalent/supramolecular anchoring) 1.2 Preparation of metalloDNAzymes (supramolecular and covalent anchoring) 1.3 Experimental characterization techniques of hybrid catalysts 1.4 Computational studies of metalloenzymes and metalloDNAzymes (from methods and models to design and optimization) 1.5 Directed evolution techniques for the optimization of metalloenzymes and metalloDNAzymes 2 APPLICATIONS 2.1 Hybrid catalysts for the hydrogenation and transfer hydrogenation reactions 2.2 Hybrid catalysts for oxidation reactions 2.3 Hybrid catalysts as Lewis acids 2.4 Hybrid catalysts for C-H activation and other X-H insertion reactions 2.5 Hybrid catalysts for allylic substitution reactions, olefin metathesis, hydroformylation, fluorination, hydrolysis,.... 2.6 Hybrid catalysts in cascade and multi-component processes 2.7 Hybrid catalysts for alternative energy harvest 2.8 Synthesis and application of hybrid catalysts with metalloenzyme-like properties 3 FUTURE PERSPECTIVES Skryť popis